The Teppen Grand Prix is a competition established out of an appreciation for stand-up comedy. As devoted fans of such performances, Yayoi Sakamoto and her two friends—Yomogi Takahashi and Yuzu Hosono—form the stand-up trio Young Wai-Wai. After qualifying for the final round in the prix, the three go up against other comedic trios, but only one group can emerge victorious. With participants housed in a famous dorm where many comedians before them have lodged, the contestants' time living at the establishment will give them a chance to prove they have what it takes to make their audience laugh until they cry! Sakamoto Yayoi, a diehard fan of comedians and comedy acts, enrolls in the private Kazuki High School in Nanba (Osakas entertainment district famous as the starting point for many comedians). She reunites with Takahashi Yomogi, a childhood friend who once formed the comedy duo Konamonzu with her when they were little. Before long, they find themselves putting together a routine at a park like they did before, in order to enter a local shopping areas contest. At that moment, a mysterious girl calls out to them.