Now in his second year of high school, Rei Kiriyama continues pushing through his struggles in the professional shogi world as well as his personal life. Surrounded by vibrant personalities at the shogi hall, the school club, and in the local community, his solitary shell slowly begins to crack. Among them are the three Kawamoto sisters—Akari, Hinata, and Momo—who forge an affectionate and familial bond with Rei. Through these ties, he realizes that everyone is burdened by their own emotional hardships and begins learning how to rely on others while supporting them in return. Nonetheless, the life of a professional is not easy. Between tournaments, championships, and title matches, the pressure mounts as Rei advances through the ranks and encounters incredibly skilled opponents. As he manages his relationships with those who have grown close to him, the shogi player continues to search for the reason he plays the game that defines his career. [Written by MAL Rewrite]

Kino, a 15-year-old traveler, forms a bond with Hermes, a talking motorcycle. Together, they wander the lands and venture through various countries and places, despite having no clear idea of what to expect. After all, life is a journey filled with the unknown. Throughout their journeys, they encounter different kinds of customs, from the morally gray to tragic and fascinating. They also meet many people: some who live to work, some who live to make others happy, and some who live to chase their dreams. Thus, in every country they visit, there is always something to learn from the way people carry out their lives. It is not up to Kino or Hermes to decide whether these asserted values are wrong or right, as they merely assume the roles of observers within this small world. They do not attempt to change or influence the places they visit, despite how absurd these values would appear. That's because in one way or another, they believe things are fine as they are, and that "the world is not beautiful; therefore, it is." [Written by MAL Rewrite]

Futaba Yoshioka used to be an attractive and popular middle-schooler—well liked by the opposite sex, but ostracized by the girls. Nevertheless, she was able to brush all that off, because the only opinion that truly mattered to her was that of Kou Tanaka, a classmate with whom she shared a shelter from rain once, followed by quite a few other precious and significant memories. She even succeeded at making plans to meet with the quiet and innocent boy at the summer festival, but a simple misunderstanding, and Tanaka's subsequent disappearance, left her walking the halls of her school friendless. Now in high school, Futaba is not your typical adolescent girl. Determined to become a class favorite this time, she avoids all unwanted attention and, instead of acting cute and feminine, only stands out through her tomboyish behavior and disheveled look. But still, her world is soon turned upside down when the only boy she ever liked unexpectedly comes into her life once again—except he goes by the name of Kou Mabuchi now, and it is not his name alone that has gone through a sea change. [Written by MAL Rewrite]

Dismissed as a hopeless loser by those around him, 27-year-old Arata Kaizaki bounces around from one job to another after quitting his first company. His unremarkable existence takes a sharp turn when he meets Ryou Yoake, a member of the ReLife Research Institute, who offers Arata the opportunity to change his life for the better with the help of a mysterious pill. Taking it without a second thought, Arata awakens the next day to find that his appearance has reverted to that of a 17-year-old. Arata soon learns that he is now the subject of a unique experiment and must attend high school as a transfer student for one year. Though he initially believes it will be a cinch due to his superior life experience, Arata is proven horribly wrong on his first day: he flunks all his tests, is completely out of shape, and can't keep up with the new school policies that have cropped up in the last 10 years. Furthermore, Ryou has been assigned to observe him, bringing Arata endless annoyance. ReLIFE follows Arata's struggle to adjust to his hectic new lifestyle and avoid repeating his past mistakes, all while slowly discovering more about his fellow classmates. [Written by MAL Rewrite]