Kino, a 15-year-old traveler, forms a bond with Hermes, a talking motorcycle. Together, they wander the lands and venture through various countries and places, despite having no clear idea of what to expect. After all, life is a journey filled with the unknown. Throughout their journeys, they encounter different kinds of customs, from the morally gray to tragic and fascinating. They also meet many people: some who live to work, some who live to make others happy, and some who live to chase their dreams. Thus, in every country they visit, there is always something to learn from the way people carry out their lives. It is not up to Kino or Hermes to decide whether these asserted values are wrong or right, as they merely assume the roles of observers within this small world. They do not attempt to change or influence the places they visit, despite how absurd these values would appear. That's because in one way or another, they believe things are fine as they are, and that "the world is not beautiful; therefore, it is." [Written by MAL Rewrite]

In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him. [Written by MAL Rewrite]

"Mushi": the most basic forms of life in the world. They exist without any goals or purposes aside from simply "being." They are beyond the shackles of the words "good" and "evil." Mushi can exist in countless forms and are capable of mimicking things from the natural world such as plants, diseases, and even phenomena like rainbows. This is, however, just a vague definition of these entities that inhabit the vibrant world of Mushishi, as to even call them a form of life would be an oversimplification. Detailed information on Mushi is scarce because the majority of humans are unaware of their existence. So what are Mushi and why do they exist? This is the question that a "Mushishi," Ginko, ponders constantly. Mushishi are those who research Mushi in hopes of understanding their place in the world's hierarchy of life. Ginko chases rumors of occurrences that could be tied to Mushi, all for the sake of finding an answer. It could, after all, lead to the meaning of life itself. [Written by MAL Rewrite]

Nana Komatsu is a helpless, naïve 20-year-old who easily falls in love and becomes dependent and clingy to those around her. Even though she nurses ambitious dreams of removing herself from her provincial roots and finding her true calling, she ends up traveling to Tokyo with the humble reason of chasing her current boyfriend Shouji Endo. Nana Osaki, on the other hand, is a proud, enigmatic punk rock vocalist from a similarly rural background, who nurtures the desire to become a professional singer. Putting her career with a fairly popular band (and her passionate romance with one of its former members) firmly behind her, she boards the same train to Tokyo as Nana Komatsu. Through a fateful encounter in their journey toward the metropolis, the young women with the same given name are brought together, sparking a chain of events which eventually result in them sharing an apartment. As their friendship deepens, the two attempt to support each other through thick and thin, their deeply intertwined lives filled with romance, music, challenges, and heartbreaks that will ultimately test their seemingly unbreakable bond. [Written by MAL Rewrite]